Biological factors driving colorectal cancer metastasis

Figure 3 Neoantigens created by oncogenesis are released and captured by dendritic cell for processing. Dendritic cells present the captured antigens on MHCI and MHCII molecules to T cells, resulting in the priming and activation of effector T-cell responses against the cancer-specific antigens. Finally, the activated effector T cells move toward and infiltrate to the tumor bed. MDSC: Myeloid-derived suppressor cells; ADCC: Antibody dependent cell mediated cytotoxicity; CTC: Circulating tumor cells; CTL: Cytotoxic T cell. Created with BioRender.com.