Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

Table 1 Clinicopathological analyses of the Prohibitin 1 expression in tumor tissues of 30 primary hepatocellular carcinoma patients

Variable	Total	PHB1		χ2 value	P value
		Negative (%)	Positive (%)
Gender
Male	21	18 (85.7)	3 (14.3)
Female	9	8 (88.9)	1 (11.1)	0.055	0.815
Age (yr)
< 50	11	9 (81.8)	2 (18.2)
≥ 50	19	17 (89.5)	2 (10.5)	0.353	0.552
Tumor size
≤ 3 cm	18	15 (83.3)	3 (16.7)
> 3 cm	12	11 (91.7)	1 (8.3)	0.433	0.511
Tumor differentiation
Poor	23	22 (95.7)	1 (4.3)
Well & moderate	7	4 (57.1)	3 (42.9)	6.887	0.009
TMN stage
Ⅰ/Ⅱ	9	6 (66.7)	3 (33.3)
Ⅲ/Ⅳ	21	20 (95.2)	1 (4.8)	4.451	0.035
Extrahepatic metastases
Yes	17	14 (82.4)	3 (17.6)
No	13	12 (92.3)	1 (7.7)	0.632	0.427
Portal vein tumor thrombus
Yes	16	14 (87.5)	2 (12.5)
No	14	12 (85.7)	2 (14.3)	0.021	0.886
AFP (μg/L)
< 400	8	5 (62.5)	3 (37.5)
≥ 400	22	21 (95.5)	1 (4.5)	5.514	0.019

AFP: Alpha-fetoprotein.