Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

Table 3 Multivariate analysis of patient characteristics and their association with overall survival and progression free survival

Variable	OS				PFS
	Sig	HR	Lower	Upper	Sig	HR	Lower	Upper
Weight loss > 5%1	0.158	1.94	0.772	4.901	0.838	1.08	0.481	2.465
ECOG PS	0.512	0.754	0.325	1.753	0.043	0.381	0.150	0.968
SIRI ≥ 2.3 × 109	0.001	4.97	1.882	13.138	0.000	8.75	2.771	27.668
Chemotherapy	0.118	1.55	0.894	2.714	0.001	2.867	1.524	5.396

¹Weight loss > 5% in the 3 mo prior to diagnosis.

Sig: Significance; HR: Hazard ratio; SIRI: Systemic Inflammation Response Index; OS: Overall survival; PFS: Progression free survival; ECOG PS: Eastern Cooperative Group Performance Status.