Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

Table 4 Uni- and multi-variate analyses of factors associated with 3-year replase-free survival rates in patients with colorectal cancer

Variable		Univariate analysis			Multivariate analysis
		HR	95%CI	P value	HR	95%CI	P value
Age (yr)	≥ 65/< 65	1.625	0.781-3.380	0.194
Sex	Female/male	1.503	0.724-3.118	0.274
BMI (kg/m2)	≥ 24/ < 24	0.354	0.135-0.928	0.035	0.792	0.269-2.337	0.673
Tumor site	Colon/rectum	0.986	0.469-2.074	0.970
Comorbidities	Yes/no	1.462	0.624-3.428	0.382
Sarcopenia	Yes/no	6.795	3.240-14.250	< 0.01	4.122	1.678-10.125	0.002
WBC (× 109/L)	≥ 10/< 10	1.728	0.410-7.283	0.490
Platelet (× 109/L)	≥ 300/< 300	1.294	0.392-4.276	0.673
Hemoglobin (g/L)	≥ 90/< 90	0.492	0.199-1.214	0.124
CRP (mg/L)	> 10/≤ 10	1.625	0.491-5.382	0.427
CEA (ng/mL)	≥ 3.4/< 3.4	2.356	1.072-5.177	0.033	2.220	0.989-4.984	0.053
CA199 (U/mL)	≥ 37/< 37	1.483	0.352-6.243	0.591
Postoperative complications	Yes/no	1.028	0.300-3.529	0.965
TNM stage	Ⅲ/Ⅰ,Ⅱ	3.477	1.581-7.650	0.002	3.603	1.612-8.053	0.002
CONUT score	≥ 5/≤ 4	4.724	2.177-10.254	< 0.01	2.992	1.241-7.212	0.015

95%CI: 95% confidence interval; HR: Hazard ratio; BMI: Body mass index; WBC: White blood cell; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; CONUT: Controlling nutritional status; CRP: C-reactive protein.