Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

doi:10.4251/wjgo.v16.i2.314

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Feb 15, 2024; 16(2): 314-330
Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.314

Table 3 Basic information of patients expressing BECN1, n (%)

Characteristic	Category	*Low expression of BECN1, n = 322*	*High expression of BECN1, n = 322*	P value
T stage	T1	11 (1.7)	9 (1.4)	0.599
	T2	58 (9.0)	53 (8.3)
	T3	210 (32.8)	226 (35.3)
	T4	41 (6.4)	33 (5.1)
N stage	N0	179 (28.0)	189 (29.5)	0.523
	N1	76 (11.9)	77 (12.0)
	N2	65 (10.2)	54 (8.4)
M stage	M0	246 (43.6)	229 (40.6)	0.496
M stage	M1	42 (7.4)	47 (8.3)
Primary therapy outcome	PD	16 (5.1)	17 (5.4)	0.775
	SD	2 (0.6)	3 (1.0)
	PR	10 (3.2)	6 (1.9)
	CR	128 (41)	130 (41.7)
Sex	Female	149 (23.1)	152 (23.6)	0.874
Sex	Male	173 (26.9)	170 (26.4)
CEA level	≤ 5	126 (30.4)	135 (32.5)	0.477
CEA level	> 5	68 (16.4)	86 (20.7)
Perineural invasion	No	58 (24.7)	117 (49.8)	0.310
Perineural invasion	Yes	15 (6.4)	45 (19.1)
Lymphatic invasion	No	160 (27.5)	190 (32.6)	0.014
Lymphatic invasion	Yes	131 (22.5)	101 (17.4)
History of colon polyps	No	177 (31.9)	200 (36)	< 0.001
History of colon polyps	Yes	113 (20.4)	65 (11.7)
Neoplasm type	Colon adenocarcinoma	234 (36.3)	244 (37.9)	0.417
Neoplasm type	Rectum adenocarcinoma	88 (13.7)	78 (12.1)
Age in yr, median (IQR)		69.0 (62.0, 77.0)	65.5 (55.3, 75.0)	< 0.001

CDK9: Cyclin-dependent kinase 9; CEA: Carcinoembryonic antigen; PD: Progressive disease; PR: Partial response; SD: Stable disease; CR: Complete response; IQR: Interquartile range.

Citation: Zheng L, Lu J, Kong DL. Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer. World J Gastrointest Oncol 2024; 16(2): 314-330
URL: https://www.wjgnet.com/1948-5204/full/v16/i2/314.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i2.314