Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

Table 1 Basic information of patients expressing cyclin-dependent kinase 9, n (%)

Characteristic	Category	Low expression of CDK9, n = 322	High expression of CDK9, n = 322	P value
T stage	T1	10 (1.6)	10 (1.6)	0.014
	T2	61 (9.5)	50 (7.8)
	T3	225 (35.1)	211 (32.9)
	T4	24 (3.7)	50 (7.8)
N stage	N0	192 (30.0)	176 (27.5)	0.108
	N1	78 (12.2)	75 (11.7)
	N2	49 (7.7)	70 (10.9)
M stage	M0	236 (41.8)	239 (42.4)	0.368
	M1	39 (6.9)	50 (8.9)
Primary therapy outcome	PD	13 (4.2)	20 (6.4)	0.185
	SD	1 (0.3)	4 (1.3)
	PR	10 (3.2)	6 (1.9)
	CR	138 (44.2)	120 (38.5)
Sex	Female	143 (22.2)	158 (24.5)	0.269
	Male	179 (27.8)	164 (25.5)
CEA level	≤ 5	135 (32.5)	126 (30.4)	0.944
	> 5	81 (19.5)	73 (17.6)
Perineural invasion	No	82 (34.9)	93 (39.6)	0.621
	Yes	31 (13.2)	29 (12.3)
Lymphatic invasion	No	193 (33.2)	157 (27)	0.008
	Yes	101 (17.4)	131 (22.5)
History of colon polyps	No	192 (34.6)	185 (33.3)	1.000
	Yes	91 (16.4)	87 (15.7)
Neoplasm type	Colon adenocarcinoma	235 (36.5)	243 (37.7)	0.528
	Rectum adenocarcinoma	87 (13.5)	79 (12.3)
Age in yr, median (IQR)		68.5 (60.0, 76.8)	67.0 (57.0, 75.0)	0.104

CDK9: Cyclin-dependent kinase 9; CEA: Carcinoembryonic antigen; PD: Progressive disease; PR: Partial response; SD: Stable disease; CR: Complete response; IQR: Interquartile range.