Signet-ring cell carcinoma of the transverse colon in a 10-year-old girl: A case report

Figure 2 Pathological features of signet-ring cell carcinoma. A: Tumor cells were distributed diffusely around the normal mucosal glands. Most tumor cells exhibited a signet-ring appearance due to cytoplasmic mucus crimping their nuclei (orange arrowhead) [hematoxylin and eosin (H&E), 400 ×]; B: Typical signet ring cells (orange arrowhead) (H&E, 400 ×); C: E-cadherin (+) showing E-cadherin was weaker in tumor cells with poor adhesion (orange arrowhead) (immunohistochemistry, 400 ×); D: Alcian Blue/Phosphoric Acid Schiff staining revealed blue-stained mucus distributed both inside and outside the cells (orange arrowhead indicates mucus) (special staining, 400 ×).