Case Report
Copyright ©The Author(s) 2024.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4738-4745
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4738
Figure 3
Figure 3 Neuroendocrine tumor component. A-E: Well-differentiated neuroendocrine tumor component. Hematoxylin and eosin (H&E), 400 ×. The tumor is weakly positive for PanCK AE1/AE3 (B), strongly positive for INSM1 and synaptophysin (C and D), proliferative index Ki67 is very low (< 3%, E); F-J: Intermingled pancreatic ductal adenocarcinoma (yellow arrow) and well-differentiated neuroendocrine tumor (blue arrow). Hematoxylin and eosin, 40 ×. Perineural invasion is evident (F); Immunohistochemical stain for CK7 is positive for both component (G); CK20 is negative in both (H); INSM1 and synaptophysin are positive in well-differentiated neuroendocrine tumor (and neurons) (I and J).