Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression

Figure 5 Matrine impedes proliferation, invasion and migration in colorectal cancer by downregulating shank-associated RH domain interactor. A: The viability of colorectal cancer (CRC) cells using the cell counting kit-8 assay in 4 groups [control (con), si-Shank-associated RH domain interactor (SHARPIN), matrine, siSHARPIN + matrine]; B: The invasion cells of CRC in 4 groups; C: The wound healing of CRC cells in 4 groups. ^cP < 0.05 vs con,^dP < 0.01 vs con; ^eP < 0.05 vs siSHARPIN,^fP < 0.01 vs siSHARPIN; ^gP < 0.05 vs matrine,^hP < 0.01 vs matrine; Con: Control group; SHARPIN: Shank-associated RH domain interactor; siSHARPIN: SHARPIN knockdown group; matrine: Matrine group; siSHARPIN + matrine: Matrine and SHARPIN knockdown group; CRC: Colorectal cancer.