Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study

Table 2 Hepatocarcinogenesis hazard ratio in Cox and competing risk regression analysis

Parameter	Univariate Cox regression analysis		Multivariable Cox regression analysis		Multivariable competitive risk regression analysis
	aHR (95%CI)	P value	aHR (95%CI)	P value	aHR (95%CI)	P value
Age	1.023 (1.018-1.027)	< 0.001	1.029 (1.024-1.034)	< 0.001	1.025 (1.020-1.030)	< 0.001
Sex (male)	1.321 (1.174-1.487)	< 0.001	1.537 (1.359-1.738)	< 0.001	1.482 (1.313-1.673)	< 0.001
Diabetes	1.155 (1.019-1.309)	0.025
Hypertension	1.128 (0.984-1.292)	0.084
Coronary disease	0.951 (0.680-1.330)	0.769
HBV	1.801 (1.602-2.025)	< 0.001	1.963 (1.742-2.211)	< 0.001	1.950 (1.734-2.193)	< 0.001
HCV	1.837 (1.352-1.981)	< 0.001	1.567 (1.293-1.900)	< 0.001	1.533 (1.274-1.846)	< 0.001
HBV and HCV	2.062 (1.068-3.980)	0.031	2.456 (1.270-4.747)	0.008	2.074 (1.038-4.143)	0.039
Decompensation	1.146 (1.015-1.295)	0.028
ALT	1.000 (1.000-1.000)	0.974
AST	1.000 (1.000-1.000)	0.815
Albumin	0.976 (0.967-0.985)	< 0.001	0.986 (0.977-0.995)	0.002	0.995 (0.987-1.005)	0.381
Globulin	1.017 (1.010-1.023)	< 0.001	1.016 (1.009-1.023)	< 0.001	1.012 (1.005-1.019)	< 0.001
INR	1.271 (1.084-1.490)	0.003
Prothrombin time	1.016 (1.002-1.031)	0.024
Direct bilirubin	1.000 (0.999-1.001)	0.943
Triglycerides	0.854 (0.776-0.939)	0.001
Hemoglobin	1.004 (1.002-1.006)	< 0.001
γ-GT	1.000 (0.999-1.000)	0.075
AFP	1.000 (1.000-1.001)	0.543
CA19-9	1.000 (0.999-1.001)	0.713
Platelets	0.999 (0.998-1.000)	0.017	0.999 (0.998-1.000)	0.015	0.998 (0.998-1.000)	0.011
Neutrophils	0.998 (0.976-1.020)	0.829
Serum ammonia	1.002 (1.001-1.003)	0.004	1.002 (1.001-1.003)	0.003	1.002 (1.001-1.003)	< 0.001
MELD	0.999 (0.990-1.008)	0.843

HBV: Hepatitis B virus; HCV: Hepatitis C virus; MELD: Model for end-stage liver disease; ALT: Alanine aminotransferase; AST: Aspartate transaminase; INR: International normalized ratio; γ-GT: Gamma-glutamyltransferase; AFP: Alpha fetoprotein; CA: Carbohydrate antigen; aHR: Adjusted hazard ratio; CI: Confidence interval.