Prognostic utility of gamma-glutamyl transpeptidase to platelet ratio in patients with solitary hepatitis B virus-related hepatocellular carcinoma after hepatectomy

Table 3 Univariate and multivariate Cox-regression analyses predicting recurrence-free survival before and after propensity score matching

Variables	Before propensity matching				After propensity matching
	Uni-HR (95%CI)	P value	Multi-HR (95%CI)	P value	Uni-HR (95%CI)	P value	Multi-HR (95%CI)	P value
Sex (male/female)	1.32 (1.03-1.69)	0.028	1.19 (0.92-1.54)	0.176	1.09 (0.8-1.49)	0.574
Age (years) (> 50/≤ 50)	1.03 (0.87-1.22)	0.756			0.93 (0.73-1.19)	0.575
Body mass index (> 24/≤ 24)	1.13 (0.94-1.36)	0.185			1 (0.77-1.29)	0.989
Smoking (yes/no)	1.11 (0.93-1.32)	0.244			1.01 (0.78-1.31)	0.93
Drinking (yes/no)	1 (0.84-1.2)	0.972			0.85 (0.64-1.11)	0.23
Diabetes mellitus (yes/no)	1.4 (0.98-2)	0.067			1.22 (0.71-2.1)	0.461
Hypertension (yes/no)	0.81 (0.6-1.09)	0.165			0.83 (0.54-1.26)	0.38
Family cases (yes/no)	0.89 (0.68-1.16)	0.384			0.76 (0.51-1.14)	0.192
Liver flukes (yes/no)	1.14 (0.93-1.4)	0.204			1.01 (0.74-1.38)	0.945
Cirrhosis (yes/no)	1.27 (1.08-1.5)	0.005	1.25 (1.05-1.49)	0.012	1.3 (1.03-1.65)	0.03	1.33 (1.04-1.68)	0.021
Child-Pugh (B/A)	1.08 (0.54-2.18)	0.823			1.01 (0.32-3.14)	0.99
Barcelona Clinic Liver Cancer stage (A/0)	1.4 (1.09-1.8)	0.008	1.14 (0.87-1.49)	0.348	1.39 (0.98-1.97)	0.061
Total bilirubin (μmol/L) (> 20.5/≤ 20.5)	0.87 (0.67-1.13)	0.292			0.85 (0.6-1.22)	0.386
Albumin (g/L) (> 40/≤ 40)	1.36 (1.15-1.61)	< 0.001	1.17 (0.98-1.4)	0.084	1.21 (0.96-1.54)	0.112
Alpha-fetoprotein (ng/mL) (≥ 200/< 200)	1.31 (1.1-1.55)	0.002	1.29 (1.08-1.54)	0.005	1.22 (0.96-1.55)	0.111
Hepatitis B virus DNA (IU/mL) (> 1000/≤ 1000)	0.8 (0.68-0.95)	0.009	0.9 (0.76-1.06)	0.214	0.76 (0.6-0.96)	0.023	0.8 (0.63-1.02)	0.067
Tumor size (cm) (≤ 5/> 5)	0.6 (0.51-0.71)	< 0.001	0.67 (0.55-0.81)	< 0.001	0.79 (0.62-1.02)	0.07
Microvascular invasion (yes/no)	1.4 (1.16-1.68)	< 0.001	1.1 (0.9-1.33)	0.359	1.18 (0.9-1.56)	0.233
Infiltrative growth (yes/no)	1.24 (1.05-1.47)	0.013	1.28 (1.08-1.53)	0.005	1.24 (0.97-1.57)	0.082
Gamma-glutamyl transpeptidase-to-platelet ratio (≤ 0.2/> 0.2)	0.49 (0.4-0.6)	< 0.001	0.53 (0.43-0.65)	< 0.001	0.56 (0.44-0.71)	< 0.001	0.57 (0.44-0.73)	< 0.001

Uni-HR: Hazard ratio for univariable Cox-regression analyses; Multi-HR: Hazard ratio for multivariable Cox-regression analyses.