Prognostic utility of gamma-glutamyl transpeptidase to platelet ratio in patients with solitary hepatitis B virus-related hepatocellular carcinoma after hepatectomy

Table 2 Univariate and multivariate Cox-regression analyses predicting overall survival before and after propensity score matching

Variables	Before propensity matching				After propensity matching
	Uni-HR (95%CI)	P value	Multi-HR (95%CI)	P value	Uni-HR (95%CI)	P value	Multi-HR (95%CI)	P value
Sex (male/female)	1.44 (1.01-2.05)	0.043	1.3 (0.9-1.87)	0.159	1.22 (0.79-1.87)	0.364
Age (years) (> 50/≤ 50)	1.02 (0.81-1.29)	0.85			0.86 (0.63-1.19)	0.362
Body mass index (> 24/≤ 24)	1.16 (0.9-1.49)	0.255			1.25 (0.88-1.79)	0.218
Smoking (yes/no)	1.05 (0.83-1.34)	0.672			1.04 (0.74-1.48)	0.81
Drinking (yes/no)	0.9 (0.7-1.15)	0.412			0.85 (0.59-1.23)	0.388
Diabetes mellitus (yes/no)	0.75 (0.4-1.41)	0.372			0.46 (0.15-1.45)	0.186
Hypertension (yes/no)	0.82 (0.54-1.24)	0.345			0.66 (0.36-1.23)	0.192
Family cases (yes/no)	0.79 (0.53-1.17)	0.234			0.61 (0.34-1.1)	0.098
Liver flukes (yes/no)	0.88 (0.65-1.19)	0.392			0.75 (0.47-1.18)	0.214
Cirrhosis (yes/no)	1.21 (0.96-1.53)	0.1			1.24 (0.9-1.71)	0.18
Child-Pugh (B/A)	2.16 (1.07-4.36)	0.032	1.78 (0.87-3.63)	0.115	1.34 (0.33-5.42)	0.679
Barcelona Clinic Liver Cancer stage (A/0)	1.93 (1.31-2.83)	< 0.001	1.51 (1-2.26)	0.048	2.03 (1.19-3.45)	0.009	1.64 (0.94-2.86)	0.082
Total bilirubin (μmol/L) (> 20.5/≤ 20.5)	0.85 (0.6-1.21)	0.37			0.9 (0.55-1.45)	0.651
Albumin (g/L) (> 40/≤ 40)	1.35 (1.07-1.71)	0.012	1.16 (0.91-1.48)	0.229	1.2 (0.87-1.65)	0.26
Alpha-fetoprotein (ng/mL) (≥ 200/< 200)	1.38 (1.09-1.74)	0.006	1.35 (1.06-1.72)	0.013	1.37 (0.99-1.89)	0.055
Hepatitis B virus DNA (IU/mL) (> 1000/≤ 1000)	0.73 (0.58-0.92)	0.008	0.83 (0.66-1.05)	0.123	0.72 (0.52-0.99)	0.042	0.82 (0.59-1.12)	0.213
Tumor size (cm) (≤ 5/> 5)	0.57 (0.46-0.72)	< 0.001	0.74 (0.57-0.95)	0.019	0.6 (0.43-0.82)	0.002	0.66 (0.48-0.93)	0.017
Microvascular invasion (yes/no)	1.55 (1.21-1.99)	< 0.001	1.19 (0.92-1.55)	0.186	1.2 (0.83-1.74)	0.322
Infiltrative growth (yes/no)	1.29 (1.02-1.63)	0.032	1.35 (1.06-1.7)	0.014	1.2 (0.87-1.65)	0.272
Gamma-glutamyl transpeptidase-to-platelet ratio (≤ 0.2/> 0.2)	0.48 (0.36-0.64)	< 0.001	0.52 (0.39-0.69)	< 0.001	0.49 (0.35-0.69)	< 0.001	0.5 (0.36-0.7)	< 0.001

Uni-HR: Hazard ratio for univariable Cox-regression analyses; Multi-HR: Hazard ratio for multivariable Cox-regression analyses.