BIRC3 induces the phosphoinositide 3-kinase-Akt pathway activation to promote trastuzumab resistance in human epidermal growth factor receptor 2-positive gastric cancer

Figure 2 High throughput sequencing and bioinformatics analysis screening Hub genes. A: The volcano plot was generated from mRNA sequencing analysis of NCI-N87 and NCI-N87R; B: Gene pathway analysis was performed; C: Protein interaction network analysis for BIRC3 was performed using the STRING online tools; D: the top differentially expressed genes were identified by the maximum neighborhood component centrality and neighborhood component centrality algorithms; E: Venn diagram was presented to show the top 10 genes selected using different algorithms, based on the CytoHubba online tools. FC: Fold change; DMNC: Density of maximum neighborhood component; MNC: Maximum neighborhood component.