Advances in the diagnosis and treatment of MET-variant digestive tract tumors

Figure 4 The hepatocyte growth factor/c-Met axis activates the Hedgehog pathway through downstream signaling. The hepatocyte growth factor (HGF)/c-Met axis activates the Hedgehog pathway through its downstream signaling pathway. After binding to the c-Met receptor, hepatocyte growth factor activates the extracellular signal-regulated kinase 1/2 and protein kinase B signaling pathways, further promoting the activation of GLI transcription factors, and thereby initiating the transcription activity of the Hedgehog pathway. HGF: Hepatocyte growth factor; Hh: Hedgehog; SPH: Secreted protein, acidic and rich in cysteine; MEK: Mitogen-activated protein/extracellular signal-regulated kinase; ERK: Extracellular signal-regulated kinase; STAT3: Signal transducer and activator of transcription 3; SHC: Src homology 2 domain containing; GAB: Grb2-associated binder; PI3K: Phosphoinositide 3-kinase; KIF7: Kinesin family member 7; GLI: GLI family zinc finger transcription factor; PKA: Protein kinase A; GSK-3β: Glycogen synthase kinase 3 β; AKT: Protein kinase B; mTOR: Mammalian target of rapamycin; GLIA: Glioma-associated oncogene homolog; Bcl: B-cell lymphoma; CCND: Cyclin D.