Endoscopic and pathological features of neoplastic transformation of gastric hyperplastic polyps: Retrospective study of 4010 cases

doi:10.4251/wjgo.v16.i11.4424

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4424-4435
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4424

Table 3 Analysis of gastric hyperplastic polyps with low-grade and high-grade intraepithelial neoplasia

	GHPs with low-grade IN (n = 119)	GHPs with high-grade IN (n = 17)	χ² test		Univariate analysis
	GHPs with low-grade IN (n = 119)	GHPs with high-grade IN (n = 17)	χ² value	P value	P value	OR (95%CI)
Age (mean ± SD), years	64.49 ± 1.13	67.93 ± 2.55		0.662¹	0.404	1.461 (0.600-3.555)
≤ 45 years, n (%)	8 (7)	1 (6)
45-65 years, n (%)	49 (41)	5 (30)
> 65 years, n (%)	62 (52)	11 (65)
Sex (male), n (%)	57 (48)	10 (59)	0.710	0.399	0.402	1.544 (0.554-4.355)
H. pylori infection, n (%)	20 (17)	2 (12)		0.654¹	0.655	0.702 (0.148-3.322)
Multiple polyps, n (%)	51 (43)	11 (65)	2.035	0.154	0.542	2.133 (0.741-6.145)
Polyp size (mean ± SD), cm	1.25 ± 0.07	2.2 ± 0.32	16.624	0.024	0.017
≤ 1 cm	63 (52)	3 (18)			-	1
1 cm-2 cm	46 (39)	7 (41)			0.034	6.956 (1.159-41.729)
> 2 cm	10 (8)	7 (41)			0.490	1.766 (0.352-8.865)
Endoscopic color, n (%)			3.382	0.184	0.232	2.455 (0.826-7.294)
Normal	50 (42)	4 (24)
Red	69 (58)	13 (76)
Mucosal erosion, n (%)	23 (20)	7 (41)	4.403	0.051	0.224	2.891 (0.994-8.411)
Polyp lobulation, n (%)	19 (16)	6 (35)	3.704	0.054	0.086	2.781 (0.947-8.703)
Mucosal roughness, n (%)	58 (49)	11 (65)	1.517	0.218	0.237	1.928 (0.670-5.552)
Endoscopic classification, n (%)				0.020¹	0.331
I	35 (29)	0 (0)
II	40 (34)	2 (12)
III	19 (16)	8 (47)
IV	25 (21)	7 (41)
Shape, n (%)			8.600	0.003
Non-pedunculated	75 (63)	2 (12)			-	1
Pedunculated or semi-pedunculated	44 (37)	15 (82)			0.010	7.375 (1.615-33.671)
Location, n (%)			4.451	0.103	0.302	0.632 (0.316-1.263)
Upper third	27 (23)	4 (24)
Middle third	49 (41)	11 (65)
Lower third	43 (36)	2 (12)
Background gastric mucosa, n (%)				0.553¹	0.644	1.788 (0.362-8.388)
Autoimmune gastritis	24 (20)	5 (29)
Chronic superficial gastritis	39 (33)	3 (18)
Chronic atrophic gastritis	26 (22)	5 (29)
Gastritis with IN	30 (25)	4 (24)

¹P value means using Fisher’s exact test.

OR: Odds ratio; CI: Confidence interval; GHPs: Gastric hyperplastic polyps; IN: Intraepithelial neoplasia; H. pylori: Helicobacter pylori.

Citation: Zhang DX, Niu ZY, Wang Y, Zu M, Wu YH, Shi YY, Zhang HJ, Zhang J, Ding SG. Endoscopic and pathological features of neoplastic transformation of gastric hyperplastic polyps: Retrospective study of 4010 cases. World J Gastrointest Oncol 2024; 16(11): 4424-4435
URL: https://www.wjgnet.com/1948-5204/full/v16/i11/4424.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i11.4424