Endoscopic and pathological features of neoplastic transformation of gastric hyperplastic polyps: Retrospective study of 4010 cases

doi:10.4251/wjgo.v16.i11.4424

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Nov 15, 2024 (publication date) through Oct 27, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4424-4435
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4424

Table 1 Features of gastric hyperplastic polyps in different groups and univariate logistic regression analysis of risk factors for neoplastic transformation

	GHPs without IN (n = 3874)	GHPs with IN (n = 136)	χ² test		Univariate analysis
	GHPs without IN (n = 3874)	GHPs with IN (n = 136)	χ² value	P value	P value	OR (95%CI)
Age (mean ± SD), years	57.86 ± 0.22	64.76 ± 1.04	37.178	< 0.001	< 0.001	1.761 (1.459-2.126)
≤ 45 years, n (%)	699 (18)	9 (6)
45-65 years, n (%)	1988 (51)	54 (40)
> 65 years, n (%)	1187 (31)	73 (54)
Sex, n (%)			9.057	0.011	0.003	1.672 (1.188-2.356)
Male	1423 (37)	67 (49)
Female	2451 (63)	69 (51)
H. pylori infection, n (%)	782 (20)	22 (16)	1.865	0.172	0.174	0.721 (0.450-1.155)
Multiple polyps, n (%)	1122 (29.4)	62 (46)	23.162	< 0.001	< 0.001	2.275 (1.614-3.207)
Polyp size (mean ± SD), cm	0.66 ± 0.01		203.055	< 0.001	< 0.001	3.634 (2.948-4.478)
≤ 1 cm	3406 (88)	66 (48)
1 cm-2 cm	374 (10)	53 (39)
> 2 cm	94 (2)	17 (13)
Endoscopic color, n (%)			18.626	< 0.001	0.03	0.671 (0.472-0.972)
Normal	2113 (55)	53 (40)
Red	1488 (40)	82 (60)
White	275 (5)	1 (0)
Mucosal erosion, n (%)	289 (8)	30 (22)	38.701	< 0.001	< 0.001	3.538 (2.318-5.402)
Polyp lobulation, n (%)	185 (5)	25 (18)	49.109	< 0.001	< 0.001	4.491 (2.840-7.102)
Mucosal roughness, n (%)	864 (22)	69 (51)	59.494	< 0.001	< 0.001	3.588 (2.542-5.064)
Endoscopic classification, n (%)			169.676	< 0.001	< 0.001	2.604 (2.210-3.067)
I	2480 (64)	35 (26)
II	1007 (26)	42 (31)
III	233 (6)	27 (20)
IV	155 (4)	32 (23)
Location, n (%)			23.926	< 0.001	< 0.001	1.750 (1.384-2.212)
Upper third	1457 (38)	31 (23)
Middle third	1715 (44)	60 (44)
Lower third	702 (18)	45 (33)
Background gastric mucosa, n (%)			81.877	< 0.001	< 0.001	1.699 (1.472-1.960)
Autoimmune gastritis	364 (9.4)	29 (21)
Chronic superficial gastritis	2466 (64)	42 (31)
Chronic atrophic gastritis	712 (18)	31 (23)
Gastritis with IN	332 (9)	34 (25)

OR: Odds ratio; CI: Confidence interval; GHPs: Gastric hyperplastic polyps; IN: Intraepithelial neoplasia; H. pylori: Helicobacter pylori.

Citation: Zhang DX, Niu ZY, Wang Y, Zu M, Wu YH, Shi YY, Zhang HJ, Zhang J, Ding SG. Endoscopic and pathological features of neoplastic transformation of gastric hyperplastic polyps: Retrospective study of 4010 cases. World J Gastrointest Oncol 2024; 16(11): 4424-4435
URL: https://www.wjgnet.com/1948-5204/full/v16/i11/4424.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i11.4424