Comparison of clinical features of patients with or without severe gastrointestinal complications in aggressive gastrointestinal lymphomas

Table 4 Univariate and multivariate analyses of factors associated with overall survival in aggressive primary gastrointestinal non-Hodgkin lymphoma patients with gastrointestinal complications

Characteristics	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age
≥ 60	1.29 (0.58-2.84)	0.535
< 60	Ref.	-
Gender
Male	1.83 (0.77-4.36)	0.174
Female	Ref.	-
Primary site
Esophagus or stomach	Ref.	-
Small intestine	1.53 (0.55-4.31)	0.417
Colon	1.25 (0.41-3.82)	0.697
Histopathology
ITCL + NKTCL	5.58 (2.40-13.00)	< 0.001	8.75 (2.87-26.71)	< 0.001
DLBCL + BL	Ref.	-	Ref.	-
Max tumor diameter	1.03 (0.93-1.14)	0.598
Invasive depth
Inside serous membrane	Ref.	-
Serosal layer and outside	1.15 (0.53-2.49)	0.728
LDH
Elevated	3.33 (1.51-7.33)	0.003	3.90 (1.50-10.12)	0.005
Normal	Ref.	-	Ref.	-
Virus
Yes	2.13 (0.73-6.23)	0.169
No	Ref.	-
Stage
I/II	Ref.	-	Ref.	-
III/IV	6.29 (2.35-16.82)	< 0.001	5.49 (1.58-19.09)	0.007
ECOG
0-1	Ref.	-	Ref.	-
≥ 2	13.40 (5.39-33.35)	< 0.001	24.14 (6.28-92.70)	< 0.001
N-GCB	0.28 (0.09-0.94)	0.040
CD5 +	1.47 (0.51-4.28)	0.479
CD30 +	1.58 (0.57-4.92)	0.347
Double expression
Yes	1.55 (0.58-4.12)	0.380
No	Ref.	-
KI 67 ≥ 70%
Yes	0.95 (0.42-2.12)	0.891
No	Ref.	-
Treatment
Without CT	Ref.	-	Ref.	-
CT alone	0.85 (0.24-2.97)	0.800	1.82 (0.44-7.50)	0.407
CT + Sur/RT	0.07 (0.03-0.19)	< 0.001	0.07 (0.02-0.24)	< 0.001

LDH: Lactate dehydrogenase, ECOG: Eastern cooperative oncology group; DLBCL: Diffuse large B-cell lymphoma; BL: Burkitt lymphoma; ITCL: Intestinal T-cell lymphoma; NKTCL: Natural killer/T-cell lymphoma; N-GCB: Non-germinal center B cells; CD: Cluster of differentiation; Ki: Kiel proliferation index; CI: Confidence interval; NK: Nature killer; CT: Chemotherapy; RT: Radiotherapy; Sur: Surgery; HR: Hazard ratio.