Comparison of clinical features of patients with or without severe gastrointestinal complications in aggressive gastrointestinal lymphomas

Table 2 Univariate and multivariate analyses of factors associated with gastrointestinal complications in aggressive Primary gastrointestinal non-Hodgkin lymphomas patients

Characteristics	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age
≥ 60	1.21 (0.60-2.45)	0.597
< 60	Ref.	-
Gender
Male	1.48 (0.72-3.03)	0.289
Female	Ref.	-
Primary site
Esophagus or stomach	Ref.	-	Ref.
Small intestine	6.55 (2.61-16.40)	< 0.001	3.33 (1.47-9.41)	0.009
Colon	5.60 (2.15-14.61)	< 0.001	2.50 (1.17-7.15)	0.023
Histopathology
DLBCL + BL	0.08 (0.01-0.63)	0.017	0.09 (0.01-0.83)	0.033
ITCL + NK/T	Ref.	-	Ref.	-
Max tumor diameter	1.30 (1.13-1.48)	< 0.001	1.25 (1.07-1.47)	0.005
Invasive depth
Inside serous membrane	Ref.	-	Ref.
Serosal layer and outside	6.55 (2.67-16.06)	< 0.001	3.38 (1.24-9.19)	0.017
LDH
Elevated	0.67 (0.33-1.40)	0.287
Normal	Ref.	-
Virus
Yes	0.70 (0.23-2.14)	0.529
No	Ref.	-
Stage
I/II	Ref.	-
III/IV	0.82 (0.40-1.66)	0.581
ECOG
0-1	Ref.	-	Ref.	-
≥ 2	3.35 (1.02-11.05)	0.047	1.02 (0.24-4.39)	0.974
N-GCB	0.62 (0.29-1.31)	0.207
CD5 +	0.46 (0.17-1.25)	0.128
CD30 +	1.40 (0.42-4.68)	0.584
Double expression
Yes	0.40 (0.16-0.97)	0.044	0.51 (0.17-1.52)	0.227
No	Ref.	-	Ref.	-
Ki 67 ≥ 70%
Yes	1.13 (0.54-2.25)	0.747
No	Ref.	-
Macroscopic findings
Neoplasm	0.59 (0.12-2.88)	0.515
Ulceration	0.69 (0.33-1.42)	0.311
Others	Ref.	-
Imaging findings
Neoplasticlesions	0.49 (0.21-1.17)	0.109
Others	Ref.	-

LDH: Lactate dehydrogenase, ECOG: Eastern cooperative oncology group; DLBCL: Diffuse large B-cell lymphoma; BL: Burkitt lymphoma; ITCL: Intestinal T-cell lymphoma; NKTCL: Natural killer/T-cell lymphoma; N-GCB: Non-germinal center B cells; CD: Cluster of differentiation; Ki: Kiel proliferation index; CI: Confidence interval; NK: Nature killer.