Comparison of clinical features of patients with or without severe gastrointestinal complications in aggressive gastrointestinal lymphomas

Table 1 Clinicopathologic characteristics of 124 cases of aggressive primary gastrointestinal non-Hodgkin lymphoma, n (%)

Characteristics	No-GICs (n = 64)	GICs (n = 60)	P value
Age, mean ± SD	59.8 ± 12.5	60.0 ± 14.2	0.932
≥ 60	32 (50.0)	34 (56.7)	0.573
< 60	32 (50.0)	26 (43.3)
Gender			0.427
Male	35 (54.7)	38 (63.3)
Female	29 (45.3)	22 (36.7)
Stage			0.875
I/II	29 (45.3)	29 (48.3)
III/IV	35 (54.7)	31 (51.7)
LDH			0.406
Elevated	27 (42.2)	20 (33.3)
Normal	37 (57.8)	40 (66.7)
Virus			0.876
Yes	8 (12.5)	6 (10.0)
No	56 (87.5)	54 (90.0)
ECOG			0.139
0-1	59 (92.2)	49 (41.7)
≥ 2	5 (7.8)	11 (18.3)
Depth			< 0.001
Inside serous membrane	54 (87.5)	31 (51.7)
Serosal layer and outside	8 (12.5)	29 (48.3)
Diameter, mean ± SD	4.65 ± 2.4	7.03 ± 3.7	< 0.001
Primary site			< 0.001
Esophagus or stomach	40 (62.5)	15 (25.0)
Small intestine	12 (18.8)	26 (43.3)
Colon	12 (18.8)	19 (31.7)
Histopathology			< 0.001
DLBCL + BL	63 (98.4)	49 (81.7)
ITCL + NKTCL	1 (1.6)	11 (18.3)
N-GCB	39 (60.9)	43 (71.7)	0.284
CD5 +	13 (20.3)	7 (11.7)	0.287
CD30 +	5 (7.8)	7 (11.7)	0.673
Double expression	18 (28.1)	9 (15.0)	0.121
Ki 67 ≥ 70%	39 (60.9)	40 (66.7)	0.634
Macroscopic findings			0.858
Neoplasm	29 (45.3)	30 (50.0)
Ulceration	31 (48.4)	27 (45.0)
Others	4 (6.2)	3 (5.0)
Imaging findings			0.205
Neoplasticlesions	53 (82.8)	43 (71.7)
Others	11 (17.2)	17 (28.3)

PGINHL: Primary gastrointestinal non-Hodgkin lymphomas; GICs: Gastrointestinal complications; LDH: Lactate dehydrogenase, ECOG: Eastern cooperative oncology group; DLBCL: Diffuse large B-cell lymphoma; BL: Burkitt lymphoma; ITCL: Intestinal T-cell lymphoma; NKTCL: Natural killer/T-cell lymphoma; N-GCB: Non-germinal center B cells; CD: Cluster of differentiation; Ki: Kiel proliferation index.