Intratumoural microorganism can affect the progression of hepatocellular carcinoma

Figure 4 Propionic acid played an inhibitory role as a metabolite of Propionibacterium. A: Effects of different concentrations of propionic acid (PA) on the cell viability of HUH-7 cells; B: Wound healing assay results of HUH7 cells in control, Propionibacterium and PA group; C: Changes in mobility of HUH-7 cells; D: Results of wound healing assay on hepatocellular carcinoma (HCC)-LM3 cells; E: The mobility of HCC-LM3 cells in Propionibacterium and PA groups decreased significantly; F: Transwell assay results of HUH7 and HCC-LM3 cells; G: The quantity of migrated HUH-7 cells; H: The quantity of migrated HCC-LM3 cells. ^aP < 0.0001. PA: Propionic acid.