Intratumoural microorganism can affect the progression of hepatocellular carcinoma

Figure 3 Propionibacterium inhibited the proliferation and migration of hepatocellular carcinoma cells. A: Cell viability was measured through CCK-8 assay. HUH-7 cells were exposed to Propionibacterium and its supernatant; B: The migration of HUH-7 cells in control, Propionibacterium and supernatant groups was evaluated by wound healing assay; C: Changes in mobility of HUH-7 cells; D: Results of 24 hours wound healing assay on hepatocellular carcinoma (HCC)-LM3 cells; E: Changes in migration rate of HCC-LM3 cells; F: Transwell assay of HUH-7 and HCC-LM3 cells. The migrating cells were observed using a 40 × microscope; G: The quantity of migrated HUH-7 cells; H: The quantity of migrated HCC-LM3 cells. ^aP < 0.0001, ^bP < 0.001.