Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma

Figure 5 Steroid receptor RNA activator 1 overexpression promotes phospholysine phosphohistidine inorganic pyrophosphate phosphatase expression in esophageal squamous cell carcinoma cells by sponging miRNA-363-5p. A: The delivery of miRNA-363-5p mimic caused a prominent miRNA-363-5p upregulation in EC9706 and TE1 cells; B-D: Steroid receptor RNA activator 1 (SRA1) upregulation triggered an obvious overexpressed effect on the endogenous phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) mRNA and protein levels in EC9706 and TE1 cells, whereas the delivery of miRNA-363-5p mimic counteracted such effect; E: LHPP expression was positively correlated with SRA1 expression in ESCC tissues; F: SRA1, miRNA-363-5p, and LHPP were preferentially concentrated in the anti-Ago2 precipitate. ^aP < 0.01 vs NC; ^bP < 0.01 vs pcDNA3.1-SRA1 + miRNA-363-5p mimic; ^cP < 0.01 vs IgG; NC: Negative control; SRA1: Steroid receptor RNA activator 1; LHPP: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase.