Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids: A case report

Table 1 Changes of tumor markers at different time points during treatment

Indicators	AFP (ng/mL)	CA19-9 (U/mL)	CEA (ng/mL)	CA125 (U/mL)	CA15-3 (U/mL)
On admission	2.23	136.13	16.68	1000	112
After treatment for 2 weeks	5.86	127.24	20.25	1210	122
After organoid-based treatment for 4 cycles	2.12	43.84	4.21	16	12.2
First year after surgery	2.3	39.67	2.62	21.2	10.6

AFP: Alpha fetal protein; CA: Carbohydrate antigen; CEA: Carcinoembryonic antigen.