Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

Figure 4 Analysis of molecular docking and clinical relevance. A: Pachymic acid docked with the top 6 core target molecules with degree value; B: Copy number analysis of the top ten core targets in gastric cancer (GC); C: Correlation analysis between GC and paracancerous sites of the top ten core targets; D: GC grading and staging analysis of the top ten core targets; E: Survival analysis of the top ten core targets. SRC: Proto-oncogene tyrosine-protein kinase Src; MAPK1: Mitogen-activated protein kinase 1; PI3KR1: Phosphatidylinositol 3-kinase regulatory subunit alpha; HSP90AA1: Heat shock protein 90-alpha; PTPN11: Tyrosine-protein phosphatase non-receptor type 11; GRB2: Growth factor receptor-bound protein 2; RXRA: Retinoic acid receptor RXR-alpha; MAPK14: Mitogen-activated protein kinase 14; EGFR: Epidermal growth factor receptor; ESR1: Estrogen receptor.