Prognostic significance and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer: A clinicopathological study

Figure 5 Co-expression of high pSMAD3L(204) and VEGFR-1, TGF-β1, or pSMAD3C(S423/425) are associated with reduced overall survival in patients with gastric cancer. Kaplan-Meier survival curves of gastric cancer patients were generated based on the expression levels of pSMAD3L(S204) combined with expressions of VEGFR-1, TGF-β1, and pSMAD3C(S423/425). A: Patients with high pSMAD3L(S204) and high VEGFR-1 exhibited the worst overall survival (OS) compared with other patients in the cohort; B: Patients with simultaneously high levels of pSMAD3L(S204) and VEGFR-1 had shorter OS than other patients; C and D: Patients with concurrent high expression of pSMAD3L(S204) and pSMAD3C(S423/425) had reduced OS compared to other patients; E and F: Patients with simultaneously high expression of pSMAD3L(S204) and TGF-β1 had shorter OS compared to other patients.