C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

Table 1 The correlations between the C-reactive protein to albumin ratio and clinicopathological factors, n (%)

	CAR ≤ 1.20 (n = 94)	CAR > 1.20 (n = 66)	Total (n = 160)	P value
Age (yr)				0.143
≤ 60	75 (79.8)	46 (69.7)	121 (75.6)
> 60	19 (20.2)	20 (30.3)	39 (24.4)
Gender				0.045
Male	77 (81.9)	57 (86.4)	134 (83.8)
Female	17 (18.1)	9 (13.6)	26 (16.3)
Hepatitis infection				0.988
No	17 (18.1)	12 (18.2)	29 (18.1)
Yes	77 (81.9)	54 (81.8)	131 (81.9)
Child-Pugh grade				0.749
A	75 (79.8)	54 (81.8)	129 (80.6)
B	19 (21.2)	12 (18.2)	31 (19.4)
AFP level (ng/L)				0.365
≤ 400	58 (61.7)	36 (54.5)	94 (58.8)
> 400	36 (38.3)	30 (45.5)	66 (41.3)
ECOG PS				0.990
0	30 (31.9)	21 (31.8)	51 (31.9)
≥ 1	64 (68.1)	45 (68.2)	109 (68.1)
Tumor size (cm)				0.248
≤ 5	26 (27.7)	13 (19.7)	39 (24.4)
> 5	68 (72.3)	53 (80.3)	121 (75.6)
Tumor number				0.512
Single	18 (19.1)	10 (15.2)	28 (17.5)
Multiple	76 (80.9)	56 (84.8)	132 (82.5)
Macroscopic vascular invasion				0.013
Absent	60 (63.8)	29 (43.9)	89 (55.6)
Present	34 (36.2)	37 (56.1)	71 (44.4)
Extrahepatic metastasis				0.173
Absent	41 (43.6)	36 (54.5)	77 (48.1)
Present	53 (56.4)	30 (45.5)	83 (51.9)
Diabetes				0.955
No	84 (89.4)	59 (89.4)	143 (89.4)
Yes	10 (10.6)	7 (10.6)	17 (10.6)
Hypertension				0.455
No	81 (86.2)	54 (81.8)	135 (84.4)
Yes	13 (13.8)	12 (18.2)	25 (15.6)
Smoke				0.013
No	60 (63.8)	29 (43.9)	89 (55.6)
Yes	34 (36.2)	37 (56.1)	71 (44.4)
Drink				0.364
No	51 (54.3)	31 (47.0)	82 (51.2)
Yes	43 (45.7)	35 (53.0)	78 (48.8)
Cirrhosis				0.191
No	40 (42.6)	35 (53.0)	75 (46.9)
Yes	54 (57.4)	31 (47.0)	85 (53.1)
Previous Ablation				0.119
No	87 (92.6)	56 (84.8)	143 (89.4)
Yes	7 (7.4)	10 (15.2)	17 (10.6)
Previous TACE				0.505
No	52 (55.3)	40 (60.6)	92 (57.)
Yes	42 (44.7)	26 (39.4)	68 (42.5)
Previous Surgery				0.701
No	57 (60.6)	42 (63.6)	99 (61.9)
Yes	37 (39.4)	24 (36.4)	61 (38.1)
BCLC stage				0.966
A	6 (6.4)	4 (6.1)	10 (6.3)
B	17 (18.1)	13 (19.7)	30 (18.8)
C	71 (75.5)	49 (74.2)	120 (75.0)

AFP: Alpha-fetoprotein; ECOG PS: Eastern Cooperative Oncology Group performance status; CAR: C-reactive protein to albumin ratio; TACE: Transcatheter arterial chemoembolization; BCLC: Barcelona Clinic Liver Cancer.