Comparative study between Embosphere® and Marine gel® as embolic agents for chemoembolization of hepatocellular carcinoma

Table 2 Univariate and multivariate analysis of prognostic factors for local progression-free survival

Parameter	Univariable analysis			Multivariable analysis
	HR	95%CI	P value	HR	95%CI	P value
Group (embosphere vs marine gel)	1.121	0.339-3.707	0.851
Age (> 65 vs ≤ 65)	1.444	0.383-5.448	0.58
Sex (male vs female)	2.628	0.336-20.55	0.34
HBV (positive vs negative)	1.911	0.558-6.540	0.29
Platelet (≤ 120 vs > 120) (103/mm3)	1.939	0.567-6.630	0.28
Serum albumin (≤ 3.5 vs > 3.5) (g/dL)	25.03	0.012-5251.5	0.20
Total bilirubin (> 1.0 vs ≤ 1.0) (mg/dL)	26.63	0.026-2756.8	0.14
PT (> 1.2 vs ≤ 1.2) (INR)	26.33	0.024-2905.2	0.15
ALT (> 40 vs ≤ 40) (IU/L)	1.088	0.235-5.040	0.91
AST (> 40 vs ≤ 40) (IU/L)	3.528	0.451-27.62	0.20
AFP (> 100 ng/mL vs ≤ 100 ng/mL)	5.407	1.572-18.60	0.003	5.130	1.479-17.79	0.01
PIVKA (> 100 mAU/mL vs 100 mAU/mL)	1.233	0.266-5.719	0.79
Tumor size (> 2 cm vs ≤ 2 cm)	1.040	0.275-3.935	0.953

HR: Hazard ratio; CI: Confidence interval; HBV: Hepatitis B virus; PT: Prothrombin time; INR: International normalized ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; AFP: Alpha-fetoprotein; PIVKA: Prothrombin induced by vitamin K deficiency or antagonist.