MicroRNA-363-3p inhibits colorectal cancer progression by targeting interferon-induced transmembrane protein 1

Figure 1 MicroRNA-363-3p is downregulated in colorectal cancer tissues and inhibits clonogenic survival, proliferation and migration of colorectal cancer cells. A: Quantitative polymerase chain reaction (qPCR) analysis of microRNA-363-3p (miR-363-3p) expression in colorectal cancer tissues and paired normal colorectal tissues; B: qPCR analysis of miR-363-3p expression in human colorectal cancer cell lines; C: Representative images of clonogenic survival of SW1116 cells transfected with agomir-363-3p or agomir-NC. The graph shows the number of colonies; D: Proliferation curve of SW1116 cells transfected with agomir-363-3p or agomir-NC; E: Representative images of the gaps at 0 and 24 h after scratching. SW1116 cells were transfected with agomir-363-3p or agomir-NC. The graph shows the relative migration distance. The scale bar is 200 μm; F: Representative images of clonogenic survival of SW480 cells transfected with antagomir-363-3p or antagomir-NC. The graph shows the number of colonies; G: Proliferation curve of SW480 cells transfected with antagomir-363-3p or antagomir-NC; H: Representative images of the gaps at 0 and 24 h after scratching. SW480 cells were transfected with antagomir-363-3p or antagomir-NC. The graph shows the relative migration distance. The scale bar is 200 μm. The results were shown as the mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. miR-363-3p: MicroRNA-363-3p; NC: Negative control.