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©The Author(s) 2023.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1520-1530
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Figure 3 MALAT1 modulates acetylation in promoter region epidermal growth factor-like domain-containing protein 7 located in histone H3.
A: Transfection of small interfering MALAT1 reduces acetylation on promoter region of EGFL7 gene (Epidermal growth factor-like domain-containing protein 7), decreasing metastasis, cell invasion and migration; B: Plasmid cloning DNA-MALAT1 transfection increases EGFL7 acetylation and protein expression, promoting migration, invasion, and metastasis of GC cells. EGFL7: Epidermal growth factor-like domain-containing protein 7; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; siMALAT1: Small interfering RNA MALAT1; pcDNA-MALAT1: Plasmid cloning DNA-MALAT1; siEGFL7: Small interfering RNA EGFL7.
- Citation: Batista DMO, da Silva JMC, Gigek CO, Smith MAC, de Assumpção PP, Calcagno DQ. Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression. World J Gastrointest Oncol 2023; 15(9): 1520-1530
- URL: https://www.wjgnet.com/1948-5204/full/v15/i9/1520.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i9.1520