Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer

Table 1 Univariate and multivariate survival analysis of patients after operation for gastric cancer

Characteristic	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex		0.772
Male	0.97 (0.80, 1.18)
Female	1.00 (Reference)
Age		0.011		0.009
≥ 65 yr	1.26 (1.05, 1.50)		1.27 (1.06, 1.53)
< 65 yr	1.00 (Reference)		1.00 (Reference)
Operation method		≤ 0.001		0.076
Proximal gastrectomy	0.56 (0.45, 0.70)	≤ 0.001	0.76 (0.60, 0.97)	0.026
Distal gastrectomy	0.57 (0.46, 0.70)	≤ 0.001	0.84 (0.67, 1.05)	0.118
Total gastrectomy	1.00 (Reference)		1.00 (Reference)
Histologic grade		0.003		0.456
Low	1.41 (1.12, 1.76)		1.09 (0.86, 1.39)
High	1.00 (Reference)		1.00 (Reference)
AJCC 8 TNM T category		≤ 0.001		0.034
T4b	2.28 (1.58, 3.28)	≤ 0.001	1.19 (0.79, 1.78)	0.410
T4a	1.92 (1.34, 2.75)	≤ 0.001	0.92 (0.62, 1.37)	0.679
T3	1.65 (1.15, 2.36)	0.006	0.85 (0.58, 1.27)	0.429
T2	0.93 (0.59, 1.48)	0.766	0.70 (0.44, 1.12)	0.138
T1	1.00 (Reference)		1.00 (Reference)
AJCC 8 TNM N category		≤ 0.001		≤ 0.001
N3	3.64 (2.86, 4.64)	≤ 0.001	2.72 (2.07, 3.59)	≤ 0.001
N2	2.01 (1.54, 2.63)	≤ 0.001	1.66 (1.24, 2.22)	0.001
N1	1.43 (1.06, 1.94)	0.019	1.37 (1.00, 1.89)	0.052
N0	1.00 (Reference)		1.00 (Reference)
AJCC 8 TNM M category		≤ 0.001		≤ 0.001
M1	3.70 (2.89, 4.74)		2.78 (2.15, 3.60)
M0	1.00 (Reference)		1.00 (Reference)
Tumor Deposits		≤ 0.001		≤ 0.001
Yes	2.09 (1.72, 2.53)		1.64 (1.32, 2.03)
No	1.00 (Reference)

AJCC: American Joint Committee on Cancer; CI: Confidence interval.