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©The Author(s) 2023.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1520-1530
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Table 2 MALAT1 molecular mechanism in GC
Cell line | Molecular interactions | Main discoveries | Ref. |
MKN28, SGC7901, BCG823, GES1 | EGFL7 | MALAT1/EGFL7 axis promotes metastasis and cell invasion | Deng et al[46] |
MKN45, AGS, GES1 | EZH2/PCDH10 | MALAT1 recruits EZH2 to inhibit the synthesis of cadherin PCDH10, promoting metastasis | Qi et al[55] |
SGC7901, MKN 45, BGC823, CTC141, CTC105, GES1 | miR-122/IGF1R | miR-122/IGF1R axis causes dysregulation of MALAT1, increasing cell invasion and migration of cells | Xia et al[38] |
SGC7901, MKN45, BGC823, AGS, SGC7901NM, SGC7901M, GES1 | E-cadherin, vimentin, SLUG, SNAIL, TWIST | MALAT1 contributes to cell migration, invasion, and proliferation by upregulating EMT markers and downregulating E-cadherin | Chen et al[54] |
MKN28, MKN74, AGS | RASSF6, β-catenin | Dysregulation of MALAT1 improves the expression of β-catenin and other EMT markers, promoting metastasis | Lee et al[56] |
BGC823, SGC7901, HEK293T, GES1 | UPF1 | Overexpression of MALAT1 causes hypermethylation of the UPF1 promoter, increasing cell migration, invasion, and proliferation | Li et al[57] |
BGC823, SGC7901, MKN45, AGS, BGC803, MGC803, GES1 | VE-cadherin/β-catenin, ERK/MMP, FAK/paxillin | MALAT1 promotes angiogenesis by through vasculogenic mimicry | Li et al[49] |
BGC823, SGC7901, MKN45, MKN28, GES1 | miR-1297/HMGB2 | MALAT1/miR-1297 increases HMGB2 protein, promoting cell invasion and proliferation of cells | Li et al[52] |
SGC7901, SGC7901/VCR, BGC823 | miR-23b-3p/ATG12 | MALAT1/miR-23b-3p, promotes drug resistance via the ATG12 protein | YiRen et al[37] |
SGC7901, MKN45, MKN28, GES1 | miR-202/GLI2 | MALAT1/miR-202, increases GLI2 expression, inducing tumor progression and cell proliferation | Zhang et al[53] |
BGC823, SGC7901, GES1 | Vimentin, E-cadherin | MALAT1 decreases E-cadherin and increases vimentin expression, promoting EMT | Yang et al[58] |
BGC823, HGC27, SGC7901, GES1 | miR-183/SIRT1, PI3KCA/AKT/mTOR | MALAT1/miR-183 increases SIRT1 protein expression, increasing cell viability, and inhibiting cell apoptosis | Li et al[59] |
MGC803, GES1 | miR-181a-5p/AKT3 | MALAT1/miR-181a-5p increases AKT3 protein expression, promoting cell proliferation and inhibiting cell apoptosis | Lu et al[39] |
MKN45, SGC7901, GES1 | Vimentin, E-cadherin, SOX2 | MALAT1 increases cell stemness via the SOX2 protein, and promotes metastasis | Xiao et al[60] |
BGC823, HGC27, MKN45, AGS, GES1 | IL-21R/miR-125a | MALAT1/miR-125a increases IL-21R expression, increasing cell invasion | Yan et al[32] |
AGS, SNU1 | PI3KCA/AKT | MALAT1 contributes to cell proliferation, invasion, and migration through the PI3KCA/AKT pathway | Zhu et al[33] |
MKN45, MKN28, MGC803, MGC803/CDDP, HGC27, NCIN87, AGS, GES1 | PI3KCA/AKT | MALAT1 increases PI3KCA, AKT and STAT3 activity, promoting resistance to cisplatin | Dai et al[35] |
SGC7901, BGC823, GES1 | miR-22-3p/ErbB3 | MALAT1/miR22-3p inhibits cell apoptosis | Li et al[34] |
CTC141, CTC105, MKN45, GES1 | miR-204/MAP1LC3B/TRPM3 | MALAT1/miR-204 increases the expression of LC3B and TRPM3, promoting autophagy | Shao et al[18] |
SGC7901, BGC823, SGC7901/OXA, BGC823/OXA | miR22-3p/ZFP91 | MALAT1 increases resistance to OXA | Zhang et al[36] |
SGC7901, SGC7901/CDDP | miR-30e/ATG5 | MALAT1 acts as a ceRNA to miR-30e, raising cisplatin resistance and autophagy via the miR-30e/AGT5 axis | Zhang et al[61] |
SGC7901, MGC803, HEK293T | CCL21, miR-202-3p/SRSF1, SRSF1/mTOR | MALAT1 promotes EMT through miR-202-3p/SRSF1/ mTOR | Fu et al[45] |
- Citation: Batista DMO, da Silva JMC, Gigek CO, Smith MAC, de Assumpção PP, Calcagno DQ. Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression. World J Gastrointest Oncol 2023; 15(9): 1520-1530
- URL: https://www.wjgnet.com/1948-5204/full/v15/i9/1520.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i9.1520