Deoxyribonucleic acid methylation driven aberrations in pancreatic cancer-related pathways

Table 2 Current ongoing trails targeting epigenetic therapy (combination drugs) in Pancreatic Cancer

Drug names	Combination agents	Trail phase	NCT number
Panobinostat vorinostat	Various antineoplastic drugs	Phase 1	NCT03878524
Vorinostat	Capecitabine + radiation	Phase 1/2	NCT00948688
Tazemetostat	Durvalumab/gemcitabine	Phase 2 recruiting	NCT04705818
Durvalumab	Tazemetostat	Phase 2	NCT04705818
Romidepsin, azacitidine	Durvalumab, lenalidomide, nab-paclitaxel	Phase 1/2 recruiting	NCT04257448
Azacitidine	Chemotherapy after progression	Phase 2 active	NCT01845805
Vorinostat	Gemcitabine, sorafenib +/−, radiation	Phase 1 active	NCT02349867
CC-486 (oral azacitidine)	–	Phase 2 active	NCT01845805
Azacitidine, not recruiting	Pembrolizumab	Phase 2 active	NCT03264404
Tazemetostat	Durvalumab	Phase 2	NCT04705818
MK-8628	-	Phase 1 completed	NCT02259114
Rx-3117	Nab-paclitaxel	1,2	NCT03189914
Entinostat	Nivolumab	Phase 2 completed	NCT03250273
Decitabine	Tetrahydrouridine	Phase 1 completed	NCT02847000
Vorinostat	Capecitabine	Phase 1 completed	NCT00983268
Azacitidine	nab-Paclitaxel, carboplatin	Phase 1 completed	NCT01478685
Vorinostat	NPI-0052 (marizomib)	Phase 1 completed	NCT00667082
Azacitidine	Pembrolizumab	Phase 2 recruiting	NCT03264404
Azacitidine	Abraxane, gemcitabine	Phase 2 active	NCT01845805
Entinostat	Nivolumab	Phase 2 active	NCT03250273