LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS

Figure 5 Expression of myristoylated alanine rich protein kinase C substrate in gastric cancer cells and changes after knocking down LINC01268. A: After transfection with sh-LINC01268, the expression of LINC01268 in MGC80-3 and AGS decreased significantly; B: The relative expression levels of myristoylated alanine rich protein kinase C substrate (MARCKS) mRNA in gastric cancer cell lines MGC80-3 and AGS were higher than that in GES-1; C: After down-regulating the expression of LINC01268 in MGC80-3 and AGS, the expression level of MARCKS mRNA was significantly reduced. Expression levels were normalized to GAPDH levels. The results were shown as the mean ± SD. ^aP < 0.05, ^cP < 0.001, ^dP < 0.0001. MARCKS: Myristoylated alanine rich protein kinase C substrate; sh-NC: sh-negative control.