LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS

Figure 3 The value of LINC01268 in auxiliary diagnosis and prognostic evaluation of gastric cancer. A: The expression level of LINC01268 in preoperative plasma of 31 patients with gastric cancer (GC) was higher than that of 19 healthy controls. Expression levels were normalized to the ACTB levels. The results were shown as the mean ± SD; B: Construction of receiver operating characteristic curve of LINC01268 expression level in plasma for diagnosis of GC, area under the curve = 0.840 (95% confidence interval: 0.733-0.948, P < 0.0001); C: The prognosis of 39 patients with high expression of LINC01268 was worse than that of 23 patients with low expression (Log-rank P = 0.047); D: The prognosis of 262 GC patients with high expression of LINC01268 in the online database Kaplan-Meier plotter was worse than that of 86 patients with low expression of LINC01268 (Log-rank P = 0.032). ^dP < 0.0001. AUC: Area under the curve; HR: Hazard ratio.