Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer: A population-based study

Table 2 Univariate and multivariate Cox regression analyses of predictive factors associated with overall survival in mucinous adenocarcinoma

Variables	Subgroup	Univariable		Multivariable
		Hazard ratio	P value	Hazard ratio	P value
Age in yr	< 40	Reference	< 0.001	Reference	< 0.001
	40-69	1.15 (0.90-1.46)		1.28 (1.00-1.64)
	≥ 70	1.85 (1.45-2.35)		2.41 (1.88-3.08)
Sex	Male	Reference	0.211	/
	Female	1.06 (0.97-1.15)
Race	White	Reference	0.035	Reference	< 0.001
	Black	1.15 (1.02-1.30)		1.26 (1.11-1.43)
	Other1	0.90 (0.75-1.08)		0.92 (0.77-1.10)
Tumor site	Proximal colon	Reference	< 0.001	Reference	< 0.001
	Transverse colon	0.93 (0.79-1.09)		0.88 (0.75-1.04)
	Distal colon	1.17 (1.05-1.29)		1.15 (1.04-1.28)
	Rectum	0.92 (0.79-1.08)		1.14 (0.97-1.34)
	Appendix	0.74 (0.61-0.88)		0.58 (0.47-0.72)
Tumor size	≤ 30	Reference	< 0.001	Reference	0.625
	31-59	1.41 (1.24-1.61)		1.06 (0.92-1.22)
	≥ 60	1.57 (1.38-1.79)		1.07 (0.93-1.23)
Grade	I	Reference	< 0.001	Reference	0.073
	II	1.20 (1.04-1.39)		1.11 (0.95-1.30)
	III	1.71 (1.45-2.02)		1.23 (1.03-1.46)
	IV	2.07 (1.67-2.57)		1.26 (1.01-1.58)
Disease stage	Localized	Reference	< 0.001	Reference	0.105
	Regional	1.49 (1.33-1.67)		0.90 (0.77-1.06)
	Distant	4.32 (3.83-4.88)		1.16 (0.85-1.60)
T stage	T1	Reference	< 0.001	Reference	< 0.001
	T2	0.86 (0.63-1.16)		0.99 (0.72-1.35)
	T3	1.41 (1.08-1.85)		1.37 (1.03-1.83)
	T4	2.67 (2.03-3.50)		2.28 (1.68-3.08)
N stage	N0	Reference	< 0.001	Reference	< 0.001
	N1	1.63 (1.47-1.81)		1.72 (1.51-1.97)
	N2	2.90 (2.62-3.21)		2.58 (2.25-2.96)
M stage	M0	Reference	< 0.001	Reference	< 0.001
	M1	3.75 (3.42-4.11)		2.67 (2.01-3.55)
Surgery	Yes	Reference	< 0.001	Reference	< 0.001
	No/Unknown	5.08 (3.83-6.73)		4.82 (3.57-6.51)
Radiation	Yes	Reference	0.764	/
	No/Unknown	1.02 (0.89-1.17)
Chemotherapy	Yes	Reference	< 0.001	Reference	< 0.001
	No/Unknown	0.87 (0.80-0.95)		1.58 (1.42-1.76)

¹Defined as the Asian/Pacific Islander and American Indian/Alaska Native.