Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer

Figure 2 The interaction mechanisms between autophagy and ferroptosis in colorectal cancer (created by Figdraw). Fe²⁺: Ferrous ions; FTH1: Ferritin heavy chain 1; FTL: Ferritin light chain; NCOA4: Nuclear receptor coactivator 4; AMPK: Adenosine monophosphate-activated protein kinase; BECN1: Beclin1; p62: sequestosome 1; NRF2: Nuclear factor erythroid 2-related factor 2; KEAP1: Kelch-like ECH-associated protein 1; GPX4: Glutathione Peroxidase 4; LDs: Lipid droplets; Rab7: The small GTPase; HSC70: Heat shock cognate 71 kDa protein; HSP90: Heat shock protein 90; LAMP2A: Lysosome-associated membrane protein type 2A; CMA: Chaperone-mediated autophagy.