Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer

Table 3 Univariate and multivariate binary logistic regression analyses of variables for bone metastasis

	Univariate analysis			Multivariate analysis
Parameter	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Age	0.594	0.398-0.887	0.011	0.392	0.203-0.756	0.005
CEA	4.559	2.931-7.090	< 0.001	2.847	1.496-5.418	0.001
CA19-9	3.511	2.271-5.429	< 0.001			0.352
CA72-4	3.176	1.995-5.056	< 0.001			0.086
Erythrocyte	0.348	0.226-0.536	< 0.001	0.482	0.240-0.966	0.040
Hemoglobin	0.425	0.281-0.645	< 0.001			0.852
Leukocyte	2.102	1.426-3.099	< 0.001			0.693
Neutrophil	2.798	1.872-4.183	< 0.001			0.601
Lymphocyte	0.453	0.308-0.667	< 0.001			0.575
Platelet	0.452	0.304-0.672	< 0.001			0.066
Glucose	3.273	2.191-4.890	< 0.001			0.087
Globulin	4.367	2.861-6.667	< 0.001	4.253	2.114-8.558	< 0.001
PT	4.536	3.038-6.774	< 0.001	3.16	1.612-6.194	0.001
PTR	2.517	1.663-3.808	< 0.001			0.145
INR	2.727	1.771-4.199	< 0.001			0.072
aPTT	3.161	2.140-4.669	< 0.001	2.234	1.157-4.313	0.017
TT	0.535	0.344-0.833	0.006			0.842
FIB	3.342	2.179-5.125	< 0.001			0.193
D-dimer	5.952	3.939-8.993	< 0.001			0.956
FDP	8.103	5.271-12.457	< 0.001	3.17	1.637-6.139	0.001

The reference of parameters was set to be less than their cutoff values. aPTT: Activated partial prothrombin time; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CEA: Carcinoembryonic antigen; CI: Confidence interval; FDP: Fibrin degradation products; FIB: Fibrinogen; INR: International normalized ratio; PT: Prothrombin time; PTR: Prothrombin ratio; TT: Thrombin time.