Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer

Table 2 Area under the receiver operating characteristic curves and cutoff values of diagnostic indicators at the maximum Youden index for bone metastasis

Parameter	AUC	95%CI	Cutoff	Sen	Spe	Youden index	PPV	NPV	P value
Age	0.558	0.501-0.616	59.5	0.546	0.583	0.129	0.433	0.546	0.046
CEA	0.694	0.639-0.748	3.97	0.649	0.711	0.36	0.665	0.711	< 0.001
CA19-9	0.673	0.617-0.729	12.81	0.655	0.649	0.304	0.614	0.649	< 0.001
CA72-4	0.624	0.560-0.688	6.71	0.518	0.747	0.265	0.603	0.747	< 0.001
Erythrocyte	0.623	0.571-0.675	4.43	0.423	0.797	0.220	0.498	0.423	< 0.001
Hemoglobin	0.599	0.547-0.651	133.50	0.427	0.759	0.186	0.488	0.427	< 0.001
Leukocyte	0.587	0.532-0.641	6.28	0.492	0.685	0.177	0.529	0.685	0.002
Neutrophil	0.63	0.576-0.683	4.23	0.484	0.749	0.233	0.581	0.749	< 0.001
Lymphocyte	0.591	0.539-0.644	1.43	0.552	0.642	0.194	0.508	0.552	0.001
Platelet	0.591	0.538-0.645	167.50	0.731	0.449	0.180	0.545	0.731	0.001
Glucose	0.664	0.613-0.716	4.82	0.524	0.748	0.272	0.595	0.748	< 0.001
Globulin	0.675	0.624-0.726	28.75	0.500	0.814	0.314	0.655	0.814	< 0.001
PT	0.738	0.692-0.784	13.25	0.651	0.709	0.360	0.618	0.709	< 0.001
PTR	0.622	0.570-0.675	1.09	0.407	0.785	0.193	0.579	0.785	< 0.001
INR	0.627	0.574-0.680	1.10	0.376	0.819	0.195	0.602	0.819	< 0.001
aPTT	0.678	0.629-0.727	35.15	0.640	0.640	0.280	0.563	0.640	< 0.001
TT	0.598	0.545-0.652	15.95	0.697	0.487	0.184	0.538	0.816	< 0.001
FIB	0.616	0.562-0.669	4.06	0.423	0.820	0.243	0.630	0.820	< 0.001
D-dimer	0.756	0.710-0.801	1.03	0.690	0.728	0.418	0.645	0.728	< 0.001
FDP	0.768	0.722-0.814	2.75	0.668	0.801	0.469	0.706	0.801	< 0.001
PP	0.879	0.841-0.917	0.364	0.831	0.806	0.637	0.745	0.806	< 0.001

aPTT: Activated partial prothrombin time; AUC: Area under receiver operating characteristic curve; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CEA: Carcinoembryonic antigen; CI: Confidence interval; FDP: Fibrin degradation products; FIB: Fibrinogen; INR: International normalized ratio; NPV: Negative predictive value; PP: Prediction probability; PPV: Positive predictive value; PT: Prothrombin time; PTR: Prothrombin ratio; Sen: Sensitivity; Spe: Specificity; TT: Thrombin time.