Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer

doi:10.4251/wjgo.v15.i7.1253

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1253-1261
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1253

Table 1 Demographic and baseline characteristics of patients

Characteristic	Overall, n = 454	No bone metastasis, n = 263	Bone metastasis, n = 191	P value
Male sex	335 (73.8)	196 (74.5)	139 (72.8)	0.676
Age, yr	59 (50-67)	61 (51-67)	57 (49-66)	0.046
CEA, ng/mL	3.53 (1.73-14.65)	2.43 (1.35-4.89)	5.29 (2.90-38.31)	< 0.001
CA19-9, U/mL	12.25 (6.30-46.88)	9.89 (4.92-20.20)	22.62 (9.73-113.35)	< 0.001
CA72-4, U/mL	3.39 (1.60-12.00)	2.58 (1.57-6.78)	7.09 (1.96-21.68)	< 0.001
Erythrocyte, × 10¹²/L	4.14 (3.65-4.57)	4.27 (3.78-4.68)	4.00 (3.50-4.39)	< 0.001
Hemoglobin, g/L	124 (106-139)	127 (109-143)	119 (103-133)	< 0.001
Leukocyte, × 10⁹/L	5.69 (4.51-7.12)	5.51 (4.43-6.76)	6.20 (4.69-7.86)	0.002
Neutrophil, × 10⁹/L	3.54 (2.64-4.88)	3.23 (2.51-4.33)	4.04 (2.83-5.97)	< 0.001
Lymphocyte, × 10⁹/L	1.37 (1.08-1.81)	1.48 (1.12-1.95)	1.30 (1.02-1.63)	0.001
Platelet, × 10⁹/L	196 (150-253)	204 (160-260)	180 (140-235)	0.001
Monocyte, × 10⁹/L	0.41 (0.30-0.54)	0.42 (0.31-0.54)	0.40 (0.30-0.55)	0.713
Glucose, mmol/L	4.54 (4.17-5.07)	4.40 (4.04-4.83)	4.84 (4.39-5.55)	< 0.001
Albumin, g/L	38.11 ± 4.96	37.80 ± 4.71	38.55 ± 5.26	0.113
Globulin, g/L	26.4 (23.7-29.8)	25.5 (22.8-28.2)	28.8 (25.1-31.6)	< 0.001
PT, s	13.1 (12.5-13.8)	12.8 (12.3-13.4)	13.5 (13.0-14.4)	< 0.001
PTR	1.05 (0.99-1.10)	1.03 (0.98-1.08)	1.06 (1.01-1.12)	< 0.001
INR	1.05 (0.99-1.10)	1.03 (0.98-1.08)	1.07 (1.01-1.13)	< 0.001
aPTT, s	35.0 (31.5-38.1)	33.5 (30.8-36.8)	36.3 (33.7-39.1)	< 0.001
TT, s	16.3 (15.6-16.9)	16.4 (15.7-17.0)	16.0 (15.3-16.8)	< 0.001
FIB, g/L	3.32 (2.76-4.16)	3.21 (2.62-3.82)	3.63 (2.93-4.59)	< 0.001
D-dimer, mg/L	0.9 (0.3-2.5)	0.5 (0.1-1.1)	2.0 (0.8-6.6)	< 0.001
FDP, mg/L	1.9 (0.9-4.9)	1.2 (0.7-2.5)	4.5 (1.7-16.2)	< 0.001

Data are shown as number of cases and percentage or median and interquartile range. aPTT: Activated partial prothrombin time; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CEA: Carcinoembryonic antigen; FDP: Fibrin degradation products; FIB: Fibrinogen; INR: International normalized ratio; PT: Prothrombin time; PTR: Prothrombin ratio; TT: Thrombin time.

Citation: Wang X, Wang JY, Chen M, Ren J, Zhang X. Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer. World J Gastrointest Oncol 2023; 15(7): 1253-1261
URL: https://www.wjgnet.com/1948-5204/full/v15/i7/1253.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i7.1253