Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects

doi:10.4251/wjgo.v15.i7.1149

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 7

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4391)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-7) series.

Item

Count

PDF

WORD

HTML

2163

Figures (1-2)

265

Tables (1-7)

511

Sum=3062

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

148

Download

479

Sum=627

Publishing Process of This Article

Item

Count

Browse

167

Download

310

Sum=477

Jul 15, 2023 (publication date) through Jan 7, 2025

Times Cited of This Article

Times Cited (3)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1149-1173
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1149

Table 7 G-quadruplexes as anticancer agents

Tumor model	G-quadruplex name	Sequence (5’-3’)	Protein target	Cells	Anticancer phenotype	Ref.
Pancreatic cancer	T-22AG	GGAGGGGGAGAAGGGAGAAGGG	Nuclear protein	Panc-1	Reduces cell growth	[199]
Pancreatic cancer	AS1411	GGTGGTGGTGGTTGTGGTGGTGGTGG	Nucleolin	PANC-1	Inhibited cell proliferation	[200]
Gastric cancer	AS1411	GGTGGTGGTGGTTGTGGTGGTGGTGG	Nucleolin	KATOIIIe, HGC27	Inhibited cell proliferation	[200]
Colorectal cancer	AS1411	GGTGGTGGTGGTTGTGGTGGTGGTGG	Nucleolin	HCC 2998, HT-29, KM12, HCT-116, SW620, HCT-15, LS174T	Inhibited cell proliferation	[200]
	TBA	GGTTGGTGTGGTTGG	uL3	HCT 116p53^-/-	Impaired ribosomal RNA processing, leading to the accumulation of pre-ribosomal RNAs, arrested cells in the G2/M phase and induced early apoptosis	[201]
	L-TBA	GGTTGGTGTGGTTGG
	LQ1	GGTTGGTGTGGTTGG
	LQ2	GGTTGGGTGTGGTTGG
	LQ3	GGTTGGGTGTGGTTGG
	INT-B (T30175)	GTGGTGGGTGGGTGGGT	Not detected	HCT 116p53^-/-	Inhibited cell proliferation	[202]
	INT-BS2	GSGGTGGGTGGGTGGGT
	INT-BS5	GTGGSGGGTGGGTGGGT
	INT-BS9	GTGGTGGGSGGGTGGGT
	INT-BS13	GTGGTGGGTGGGSGGGT
	INT-BS17	GTGGTGGGTGGGTGGGS
	TT-INT-B	TTGTGGTGGGTGGGTGGGT
	Qnat	GGGTGGGTGGGTGGGT	Not detected	HCT 116p53^-/-	Inhibited cell proliferation	[203]
	QS4	GGGSGGGTGGGTGGGT
	QS8	GGGTGGGSGGGTGGGT
	QS12	GGGTGGGTGGGSGGGT
	QS16	GGGTGGGTGGGTGGGS

Citation: Han ZQ, Wen LN. Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects. World J Gastrointest Oncol 2023; 15(7): 1149-1173
URL: https://www.wjgnet.com/1948-5204/full/v15/i7/1149.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i7.1149