Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer

doi:10.4251/wjgo.v15.i7.1135

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 7

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3032)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

WORD

HTML

1964

Figures (1-2)

154

Tables (1-2)

220

Sum=2436

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

125

Download

300

Sum=425

Jul 15, 2023 (publication date) through Jul 7, 2024

Times Cited of This Article

Times Cited (3)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1135-1148
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1135

Table 2 The role of ferroptosis in colorectal cancer

Intervention	Target	Effects and mechanism	Ref.
SRSF9	GPX4↓	Inhibition of SRSF9 increases erastin-induced iron death by downregulation of GPX4 level	[74]
IMCA	SLC7A11↓	IMCA induces SLC7A11 mediated ferroptosis through AMPK/mTOR pathway	[77]
TalaA	ROS↑, SLC7A11↓	TalaA induces ferroptosis to kill CRC cells	[144]
Lipocalin 2	GPX4↑, system Xc−↑	Overexpression of Lipocalin 2 inhibits ferroptosis and promotes CRC progression	[75]
TIGAR	GSH↓, ROS↑	TIGAR induces ferroptosis resistance in CRC by ROS/AMPK/SCD1 signaling pathway	[145]
HIF-2α	Iron↑	HIF-2α activation potentiates oxidative cell death in CRCs by increasing cellular iron	[79]
TP53	Lipid peroxidation, ACSL4↑	Restricts ferroptosis by blocking DPP4 activity in a transcription independent manner TP53	[91]
Tagitinin C	NRF2/HO-1↑, lipid peroxidation	Tagitin C activates NRF2/HO-1 pathway to induce ferroptosis	[82]
Cetuximab	NRF2↓, ROS↑	Cetuximab inhibits Nrf2/HO-1 pathway to promote ferroptosis in CRC	[85]
Beta-elemene	GSH↓, GPX4↓	Combined treatment with beta-elemene and cetuximab induces ferroptosis in CRC	[96]
Vitamin C	Iron↑, ROS↑	Vitamin C limits CRC resistance to EGFR-targeted therapies	[97]
FeOOH NSs	H₂S↓	FeOOH NSs eliminate endogenous H₂S to induce ferroptosis	[99]

SRSF9: Serine and arginine rich splicing factor 9; GPX4: Glutathione peroxidase 4; IMCA: The benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide; SLC7A11: Solute carrier family 7 member 11; TalaA: Talaroconvolutin A; ROS: Reactive oxygen species; TIGAR: TP53-induced glycolysis and apoptosis regulator; GSH: Glutathione; SCD1: Stearoyl-coenzyme A desaturase-1; HIF-2α: Hypoxia-inducible factor 2α; TP53: Tumor suppressor p53; ACSL4: Acyl-CoA synthetase long-chain family member 4; NRF2: Nuclear factor erythroid 2-related factor 2; HO-1: Haem oxygenase 1; DPP4: Dipeptidyl-peptidase-4; FeOOH NSs: Iron oxide-hydroxide nanospindles; CRC: Colorectal cancer.

Citation: Zeng XY, Qiu XZ, Wu JN, Liang SM, Huang JA, Liu SQ. Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer. World J Gastrointest Oncol 2023; 15(7): 1135-1148
URL: https://www.wjgnet.com/1948-5204/full/v15/i7/1135.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i7.1135