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©The Author(s) 2023.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1135-1148
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1135
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1135
Table 1 The role of autophagy in colorectal cancer
Intervention | Target | Effects and mechanism | Ref. |
Aspirin | mTOR↓, AMPK↑ | Inhibits mTOR signal transduction and activates AMPK to induce autophagy of CRC | [33] |
TBK1 | mTORC1↓ | TBK1 initiates mTORC1 inhibition and induces autophagy to promote CRC progression | [139] |
ABHD5 | BECN1↑ | ABHD5 prevents CASP3 from cleaving BECN1 and enhances autophagy flux to inhibit CRC | [38] |
SOX2 | BECN1↑ | SOX2-β-catenin/Beclin1/autophagy signaling axis promotes chemoresistance of CRC | [41] |
FIRRE | Stabilize BECN1 | Stabilizes BECN1 and promotes autophagy in a PTBP1 mediated manner to stimulate the development of CRC | [42] |
IL-6 | BECN1↑ | IL-6/BECN1 pathway activates autophagy and promotes chemotherapy resistance of CRC | [39] |
Pelareorep | BECN1↑ | Upregulates BECN1 expression and induces autophagy to enhance CRC proliferation | [140] |
Fusobacterium nucleatum | BECN1↑, CARD3↑ | Upregulates CARD3 expression and activates autophagy signal to promote CRC metastasis | [141] |
DCZ5248 | p62↑ | Induces lysosomal acidification and weakens lysosomal cathepsin activity to inhibit autophagy | [142] |
Claudin 1 | p62↓ | Reduces the level of p62 and stimulates autophagy to promote CRC progression | [143] |
DBTTS | p62↑ | Induces accumulation of p62 protein and inhibits autophagy to induce CRC cell death | [47] |
- Citation: Zeng XY, Qiu XZ, Wu JN, Liang SM, Huang JA, Liu SQ. Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer. World J Gastrointest Oncol 2023; 15(7): 1135-1148
- URL: https://www.wjgnet.com/1948-5204/full/v15/i7/1135.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i7.1135