Transcription factor glucocorticoid modulatory element-binding protein 1 promotes hepatocellular carcinoma progression by activating Yes-associate protein 1

Figure 1 Glucocorticoid modulatory element-binding protein 1 is highly expressed in hepatocellular carcinoma. A: StarBase database (http://starbase.sysu.edu.cn/) analysis of glucocorticoid modulatory element-binding protein 1 (GMEB1) expression in hepatocellular carcinoma (HCC) tissues. B: Immunohistochemical assay was conducted to detect GMEB1 expression in HCC and para-cancerous tissues. C: IHC scores of GMEB1 expression in HCC and para-cancerous tissues. D and E: Detection by qRT-PCR of GMEB1 mRNA expression in HCC and para-cancer tissues, as well as in HCC cells (HepG2, HCCML3, MHCC97H and Huh7) and normal human hepatocytes (HL-7702). F: Detection by Western blot of GMEB1 protein expression in HCC cells and HL-7702 hepatocytes. G: The StarBase database analysis of the relationship between GMEB1 expression and HCC patients’ overall survival. ^eP < 0.001. GMEB1: Glucocorticoid modulatory element-binding protein 1; YAP1: Yes-associate protein 1.