5’tiRNA-Pro-TGG, a novel tRNA halve, promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

Figure 6 HPSE2-associated immune and metabolic profiles in colorectal cancer. A and B: Scores of immune cells and immune functions by ssGSEA in the colorectal cancer (CRC) patients of HPSE2-low and HPSE2-high groups. C: Unsupervised clustering of metabolic pathways in CRC patients of HPSE2-low and HPSE2-high groups by ssGSEA. D: Kyoto Encyclopedia of Genes and Genome pathway analysis and gene ontology enrichment analysis; E: For 5′transfer RNA halves-Pro-TGG predicted genes. The vertical axis shows the annotated functions of the predicted genes. The horizontal axis shows the ratio of different genes in the specific pathway/progress and P value (showed by colors) of each cluster, respectively. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. ns: Not significant; CRC: Colorectal cancer; KEGG: Kyoto Encyclopedia of Genes and Genome; BP: Biological process; GO: Gene ontology; HLA: Human leukocyte antigen; IFN: Interferon.