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©The Author(s) 2023.
World J Gastrointest Oncol. Jun 15, 2023; 15(6): 943-958
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.943
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.943
Table 2 In vivo studies investigating effect of vitamin E on pancreatic cancer
Type | Model | Dosing regimen | Statistically significant effect (compared to negative control) | Ref. |
δ-TT | Subcutaneous xenograft of MIA PaCa-2 induced pancreatic tumor in athymic nude mice | PO 100 mg/kg, 1 x/day for 3 wk | ↓ Tumor volume; ↓ Proliferation markers; ↓ MAPK related markers | [43] |
δ-TT | Subcutaneous xenograft of MIA PaCa-2 induced pancreatic tumor in athymic nude mice | PO 200 mg/kg, 2 x/day during weekday & 1 x/day during weekend for 4 wk | ↓ Tumor volume; ↑ Apoptotic markers | [42] |
δ-TT | Subcutaneous xenograft of L3.6pl cells and PCSC- induced pancreatic tumor in athymic nude mice | PO 200 mg/kg, 2x/day for 4 wk | ↓ Tumor volume; ↓ Proliferation markers; ↑ Apoptotic markers; ↓ Invasion markers; ↓ Angiogenesis markers | [48] |
δ-TT | Orthotopic xenograft of MIA PaCa-2 induced pancreatic tumor in athymic nude mice | PO 400 mg/kg, 1 x/day for 28 d | ↓ Tumor volume; ↓ Proliferation markers; ↓ NF-κB activity; ↓ Invasion markers; ↓ Angiogenesis markers | [41] |
δ-TT | LSLKrasG12D/+; LSLTrp53R172H/+; Pdx-1-Cre (KPC) transgenic mice | PO 200 mg/kg, 2 x/day for 12 wk | ↑ Survival; ↓ Tumor volume; = Body weight; ↓ Proliferation markers; ↑ Apoptotic markers; ↓ MAPK related markers | [49] |
δ-TT | LSLKrasG12D/+; Pdx-1-Cre transgenic mice | PO 200 mg/kg, 2 x/day for 12 mo | ↑ Apoptotic markers | [47] |
δ-TT | LSLKrasG12D/+; Pdx-1-Cre transgenic mice | PO 200 mg/kg, 2 x/day for 12 mo | ↑ Survival; ↓ Tumor progression; = Body weight; ↑ Apoptotic markers; ↓ NF-κB markers; ↓ MAPK related markers | [50] |
δ-TT | Orthotopic xenograft of MIA PaCa-2 induced pancreatic tumours in athymic nude mice | PO 50-100 mg/kg, 2 x/day during weekday & 1 x/day during weekend for 6 wk | ↑ δ-TT concentration in pancreas; = Body weight; = Histopathology | [51] |
α-TT, β-TT, γ-TT, δ-TT | Subcutaneous xenograft of AsPC-1 induced pancreatic tumor in SCID mice | PO 200 mg/kg, 2 x/day for 4 wk | ↓ Tumor volume; ↑ Apoptotic markers; ↓ Antiapoptotic markers; ↓ NF-κB activity and markers | [39] |
α-TP | N-nitrosobis (2-oxopropyl) amine-induced pancreatic cancer in Syrian hamster | PO 4 mg/kg, 3 x/wk for 12 wk | = Tumor incidence; = Body weight; ↓ Liver metastasis incidence; = Liver metastasis number; = Liver metastasis size | [37] |
α-TP | N-nitrosobis (2-oxopropyl) amine-induced pancreatic cancer in Syrian hamster | PO 4 mg/kg, 3 x/wk for 12 wk | = Tumor incidence; = Body weight; | [38] |
- Citation: Ekeuku SO, Etim EP, Pang KL, Chin KY, Mai CW. Vitamin E in the management of pancreatic cancer: A scoping review. World J Gastrointest Oncol 2023; 15(6): 943-958
- URL: https://www.wjgnet.com/1948-5204/full/v15/i6/943.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i6.943