Development of a model based on the age-adjusted Charlson comorbidity index to predict survival for resected perihilar cholangiocarcinoma

Table 1 Weighted index of comorbidities in the age-adjusted Charlson comorbidity index and patient distribution

Conditions	Training cohort (n = 244)	Validation cohort (n = 81)	Total patients (n = 325)
1 point per decade for age > 40 (0 to 4 points)
< 50	88 (36.1)	27 (33.3)	115 (35.4)
50-59	64 (26.2)	25 (30.9)	89 (27.4)
60-69	55 (22.5)	19 (23.5)	74 (22.8)
70-79	27 (11.1)	7 (8.6)	34 (10.5)
≥ 80	10 (4.1)	3 (3.7)	13 (4.0)
1 point
Mild liver disease	42 (17.2)	12 (14.8)	54 (16.6)
Peptic ulcer disease	11 (4.5)	4 (4.9)	15 (4.6)
Congestive heart failure	9 (3.6)	2 (2.4)	11 (3.4)
Peripheral vascular disease	9 (3.6)	5 (6.1)	14 (4.3)
Cerebrovascular disease	6 (2.4)	1 (1.2)	7 (2.2)
Chronic pulmonary disease	6 (2.4)	1 (1.2)	7 (2.2)
Connective tissue disease	4 (1.6)	3 (3.7)	7 (2.2)
Myocardial infarction	0 (0.0)	0 (0.0)	0 (0.0)
Dementia	0 (0.0)	0 (0.0)	0 (0.0)
Diabetes without end-organ damage	42 (17.2)	12 (14.8)	54 (16.6)
2 points
Diabetes with end-organ damage	10 (4.1)	4 (4.9)	14 (4.3)
Moderate/severe renal disease	8 (3.2)	1 (1.2)	9 (2.8)
Other tumor	0 (0.0)	0 (0.0)	0 (0.0)
Leukemia	0 (0.0)	0 (0.0)	0 (0.0)
Hemiplegia/paraplegia	0 (0.0)	0 (0.0)	0 (0.0)
Malignant lymphoma	0 (0.0)	0 (0.0)	0 (0.0)
3 points
Moderate/severe liver disease	3 (1.2)	0 (0.0)	3 (0.9)
6 points
Metastatic solid tumor	0 (0.0)	0 (0.0)	0 (0.0)
AIDS	0 (0.0)	0 (0.0)	0 (0.0)

AIDS: Acquired immune deficiency syndrome.