BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis

Figure 3 Representative cytograms and endothelial cells sprouting spheroids depict the negative impact of BZD9L1 on endothelial cell functions. A: BZD9L1 at 2.5 μM and 5.0 μM induced apoptosis; B: Cell cycle arrest at G1 phase; C: But reduced Ea.Hy 926 spheroid sprouting compared to the negative control at 72 h. Sunitinib anti-angiogenic agent was used as the positive control. Statistical analysis (^cP < 0.001), one-way ANOVA with Bonferroni posthoc test, n = 3 independent experiments using GraphPad Prism 9.4.0. Error bars represent SEM. NC: Negative control.