BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis

Figure 2 Quantitative polymerase chain reaction analysis of Ea. HY926 cells treated with BZD9L1 for 4 h. A: BZD9L1 reduced the gene expression levels of sirtuin 1 (SIRT1) and SIRT 2; B: Intercellular adhesion molecule 1 (ICAM-1), vascular endothelial cadherin (VE-cadherin) and integrin-alpha V (ITGA5) cell adhesion markers including ICAM-1, VE-cadherin and ITGA5, compared to the negative control (NC). Statistical analysis (^cP < 0.001), one-way ANOVA with Bonferroni posthoc test, n = 3 independent experiments using GraphPad Prism 9.4.0. Error bars represent SEM. SIRT: Sirtuin; ICAM-1: Intercellular adhesion molecule 1; NC: Negative control; VE-cadherin: Vascular endothelial cadherin; ITGA5: Integrin-alpha V.