Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis

Figure 1 Circ_0003356 is expressed to low levels in gastric cancer tissues. A: CircRNAs in GSE184882 were analyzed and five with the most significant expression differences in gastric cancer (GC) were used for heat map analysis; B: Relative expression of circRNAs in tumor and normal tissues determined by quantitative real-time polymerase chain reaction (qRT-PCR); C: Relative expression of circ_0003356 in tumor and normal tissues determined by qRT-PCR; D: Kaplan-Meier analysis of the correlation between circ_0003356 expression and overall survival of GC patients; E: Relative expression of circ_0003356 in GES-1, HGC-27, and AGS cells determined by qRT-PCR. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. NC: Negative control; GC: Gastric cancer.