Efficacy of image-enhanced endoscopy for colorectal adenoma detection: A multicenter, randomized trial

Table 5 Subgroup analysis of all polyps

	NBI group (n = 2016)	LCI group (n = 97)	WLI group (n = 2098)	P value1	RR (95%CI)	P value2	RR (95%CI)	P value3	RR (95%CI)
PDR	839/2016 (41.6)	43/97 (44.3)	757/2098 (36.1)	0.01	1.15 (1.07-1.25)	0.10	1.23 (0.98-1.55)	0.60	0.94 (0.75-1.18)
All polyps	1519	69	1319
Inflammatory polyp	421 (27.7)	5 (7.2)	341 (25.9)	0.26	1.07 (0.95-1.21)	0.01	0.28 (0.12-0.66)	0.01	3.83 (1.64-8.93)
Hyperplastic polyp	164 (10.8)	15 (21.7)	150 (11.4)	0.63	0.95 (0.77-1.17)	0.01	1.91 (1.19-3.07)	0.01	0.50 (0.31-0.80)
Adenoma polyp	647 (42.6)	43 (62.3)	590 (44.7)	0.25	0.95 (0.88-1.04)	0.01	1.39 (1.15-1.69)	0.01	0.68 (0.56-0.83)
Sessile serrated adenoma	10 (0.7)	0 (0)	11 (0.8)	0.59	0.79 (0.34-1.85)	1.004		1.004
Chronic inflammation	259 (17.1)	3 (4.3)	211 (16.0)	0.45	1.07 (0.90-1.26)	0.01	0.27 (0.09-0.83)	0.01	3.92 (1.29-11.93)
Cancer	13 (0.9)	3 (4.3)	13 (1.0)	0.72	0.87 (0.40-1.87)	0.044	4.41 (1.29-15.12)	0.034	0.20 (0.06-0.68)
Others	5 (0.3)	0 (0)	3 (0.2)	0.734	1.45 (0.35-6.04)	1.004		1.004
Adenoma per colonoscopy	0.32 ± 0.67	0.44 ± 0.87	0.28 ± 0.62	0.11		0.03		0.10
Adenoma polyp	647	43	590
Size				0.56		0.22		0.33
≤ 5 mm	315 (48.7)	23 (53.5)	294 (49.8)		0.98 (0.87-1.09)		1.07 (0.80-1.44)		0.91 (0.68-1.22)
6-9 mm	196 (30.3)	15 (34.9)	163 (27.6)		1.10 (0.92-1.31)		1.26 (0.82-1.94)		0.87 (0.57-1.33)
≥ 10 mm	136 (21.0)	5 (11.6)	133 (22.5)		0.93 (0.76-1.15)		0.52 (0.22-1.19)		1.81 (0.78-4.18)
Shape				0.43		0.79		1.004
Pedunculated	68 (10.5)	4 (9.3)	76 (12.9)		0.82 (0.60-1.11)		0.72 (0.28-1.88)		1.13 (0.43-2.95)
Subpedunculated	174 (26.9)	12 (27.9)	154 (26.1)		1.03 (0.86-1.24)		1.07 (0.65-1.76)		0.96 (0.59-1.58)
Flat	405 (62.6)	27 (62.8)	360 (61.0)		1.03 (0.94-1.12)		1.03 (0.81-1.31)		1.00 (0.79-1.26)
Pathology				0.90		0.684		0.67
Tubular adenoma	627 (96.9)	43 (100)	569 (96.4)		1.01 (0.98-1.03)
Tubulovillous adenoma	18 (2.8)	0 (0)	19 (3.2)		0.86 (0.46-1.63)
Villous adenoma	2 (0.3)	0 (0)	2 (0.3)		0.91 (0.13-6.45)
Site				0.57		0.294		0.31
Left	246 (38.0)	12 (27.9)	236 (40.0)		0.95 (0.83-1.09)		0.70 (0.43-1.14		1.36 (0.83-2.23)
Right	330 (51.0)	27 (62.8)	299 (50.7)		1.01 (0.90-1.12)		1.24 (0.97-1.58)		0.81 (0.64-1.04)
Rectum	71 (11.0)	4 (9.3)	55 (9.3)		1.18 (0.84-1.64)		1.00 (0.38-2.62)		1.18 (0.45-3.08)

¹The P value between narrow band imaging group and white light imaging group.

²The P value between linked color imaging group and white light imaging group.

³The P value between narrow band imaging group and linked color imaging group.

⁴Using fisher exact test.

Dates are n or n (%). Others in narrow band imaging group: Dermatofibroma × 1, fibroepithelial polyp × 1, neuroendocrine tumor × 1, soft fibroma × 1, gland hyperplasia × 1. Others in white light imaging group: Neuroendocrine tumor × 1, lymphoid polyps × 1, inflammatory granulation tissue × 1. PDR: Polyp detection rate; RR: Relative risk; NBI: Narrow band imaging; WLI: White light imaging; LCI: Linked color imaging; CI: Confidence interval.